Endocrine Abstracts

We present a case of discordant pituitary biochemistry which resolved after discontinuing a commercially available combination vitamin supplement. A 35 year-old man presented following an episode of headache and dizziness, preceding collapse and possible seizure activity. Investigations revealed deranged pituitary function: TSH 0.02 mU/l (0.35-5.50), fT4 3.6 pmol/l (10.0-20.0), 9 am cortisol 18 nmol/l (200-500), testosterone >52 nmol/l (8.4-28.7), FSH <0.3 U/l (1.0-18....

Background: The objective of this study was to observe the changes in activity of antioxidant enzymes, hepatic glucose homeostasis, lipogenic enzymes and lipid metabolism, serum lipid profile and liver function occurring in livers of female rats of 3, 12 and 24 months age groups, and to see whether these changes are restored to 3 months control levels rats after exogenous administration of steroid hormone estrogens (17-β-estradiol, E2).Methods: The ...

Introduction: Hyponatraemia is the most common electrolyte disturbance, affecting 15–20% of emergency admissions to hospital. It is associated with increased mortality and length of stay in hospital. This audit was performed to evaluate how well hyponatraemia is being investigated and managed in the Acute Assessment Unit (AAU).Methods: Sodium level on admission for all patients attending AAU at Conquest Hospital over a 1-...

Introduction: Hyponatraemia is the most common electrolyte disturbance, affecting 15–20% of emergency admissions to hospital. It is associated with increased mortality and length of stay in hospital. This audit was performed to evaluate how well hyponatraemia is being investigated and managed in the Acute Assessment Unit (AAU).Methods: Sodium level on admission for all patients attending AAU at Conquest Hospital over a 1-...

Introduction: Since chronic renal failure is accompanied with bone abnormalities, the term renal osteodystrophy has become widely accepted. In women, chronic renal failure is commonly accompanied by endocrine problems that cause irregular menstruation. The majority of investigations on renal osteodystrophy, however, have not considered the potential impact of these hormonal imbalances on the etiology of the bone changes observed in these patients.Objecti...

Introduction: Amiodarone is a widely used antiarrhythmic drug for refractory atrial or ventricular tachyarrhythmias. Amiodarone-induced thyrotoxicosis (AIT) occurs in up to 6% of patients taking this medication in iodine-sufficient areas of the world and in up to 10% in iodine deficient areas. AIT is of two types: type 1 is a form of iodine-induced hyperthyroidism whereas type 2 is a drug-induced destructive thyroiditis. Type 1 AIT tends to occur in patients with underlying th...

A 29-year-old man presented with an 18-month history of reduced libido and lethargy. His symptoms started after cessation of anabolic steroids for three years. His childhood and development history were unremarkable with normal onset of puberty and development of secondary sexual characteristics. He had no past medical or family history of note. Clinical examination demonstrated normal BMI, musculature, distribution of body hair, testicular volume, and genital size. Biochemica...

: 39Y old male who was originally treated as child with CAH secondary to 21-Hydroxylase deficiency and was put on glucocorticoids and mineralocorticoids from first week of life due to salt wasting crises. He has had very high 17-OH progesterone and adrenal androgen due to noncompliance. He developed polycythemia secondary to androgen excess, resulted in venesection. Haematologist have investigated the mutation and EPO measurement and he felt that this was probably secondary po...

This is the case 32y old Asian lady, who first presented to her GP in October 2013 with weight loss, palpitations and fatigue and found to have overactive thyroid. She has not experienced any neck pain or systemic illness. She has some neck tenderness but not goitre or any extra-thyroidal manifestation of Graves’ disease, hence the thyroid nucleotide scan was requested. His scan was consistent with thyroiditis. By January 2014 her thyroid function test normalized with TSH...

Background: Glucocorticoids are used medium and long-term for a variety of inflammatory and autoimmune conditions, with increasing use in the UK. The management of their potential side effects, however, remains suboptimal, and guidelines are not comprehensive. Our institute has had cases of patients presenting with hyperglycaemic emergencies due to steroid induced diabetes.Aims: 1) To obtain an estimate of the frequency of the use of medium and long term...